Abstract :Intrahepatic Cholestasis of Pregnancy (ICP) is the most common pregnancy-related liver disease and it is characterized by onset of pruritus and elevated serum transaminases and bile acids (BA) in the third trimester of pregnancy. Symptoms and abnormal liver tests resolve following delivery but frequently recur in subsequent pregnancies. We represent a case of 37-year-old female who had intrahepatic cholestasis of pregnancy (ICP) in three pregnancies at intervals of 2 to 10 years.